Home Neuronal Signaling ADC Cytotoxin agonist - Dopamine Receptor antagonist - 5-HT Receptor agonist Tetrahydroberberine For research use only.

Tetrahydroberberine

Synonyms: Canadine

Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.

Tetrahydroberberine Chemical Structure

Tetrahydroberberine Chemical Structure

CAS No. 522-97-4

Purity & Quality Control

Batch: S515301 DMSO]6 mg/mL]false]]]false]]]false Purity: 99.65%
99.65

Tetrahydroberberine Related Products

Biological Activity

Description Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
Targets
D2 receptor [1] 5-HT1A [1]
6.08(pKi) 5.38(pKi)
In Vivo
In vivo Oral administration of THB not only resulted in significantly accelerated gastric emptying of normal rats in a bell-shaped relationship, with a maximal efficacy at a dose of 30 μg/kg, but also restored the delayed gastric emptying caused by apomorphine, which might be mediated by an antidopaminergic effect[1].
Animal Research Animal Models Male Sprague-Dawley rats (200-220 g)
Dosages 1, 3, 10, 30, or 100 μg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 339.39 Formula

C20H21NO4
CAS No. 522-97-4 SDF --
Smiles COC1=C(C2=C(CC3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC
Storage (From the date of receipt)

In vitro
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