Tetrahydroberberine

Catalog No.S5153 Batch:S515301

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Technical Data

Formula

C20H21NO4
Molecular Weight 339.39 CAS No. 522-97-4
Solubility (25°C)* In vitro DMSO 6 mg/mL (17.67 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
Targets
D2 receptor [1] 5-HT1A [1]
6.08(pKi) 5.38(pKi)
In vivo Oral administration of THB not only resulted in significantly accelerated gastric emptying of normal rats in a bell-shaped relationship, with a maximal efficacy at a dose of 30 μg/kg, but also restored the delayed gastric emptying caused by apomorphine, which might be mediated by an antidopaminergic effect[1].

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    Male Sprague-Dawley rats (200-220 g)

  • Dosages

    1, 3, 10, 30, or 100 μg/kg

  • Administration

    i.v.

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.