Home Immunology & Inflammation ADC Cytotoxin chemical - Immunology & Inflammation related chemical Lappaconite HBr For research use only.

Lappaconite HBr

Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.

Lappaconite HBr Chemical Structure

Lappaconite HBr Chemical Structure

CAS No. 97792-45-5

Purity & Quality Control

Lappaconite HBr Related Products

Biological Activity

Description Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
In vitro
In vitro Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg/L to 40 mg/L, the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level. [1]
In Vivo
In vivo LD50: Mice 10.5mg/kg (i.p.); Rats 9.9mg/kg (i.p.) [2]

Chemical Information & Solubility

Molecular Weight 665.61 Formula

C32H44N2O8.HBr
CAS No. 97792-45-5 SDF Download Lappaconite HBr SDF
Smiles CCN1CC2(CCC(C34C2CC(C31)C5(CC(C6CC4C5(C6OC)O)OC)O)OC)OC(=O)C7=CC=CC=C7NC(=O)C.Br
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (79.62 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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