Home Neuronal Signaling ADC Cytotoxin inhibitor - GABA Receptor antagonist (+)-Bicuculline For research use only.

(+)-Bicuculline

Synonyms: d-Bicuculline

(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

(+)-Bicuculline Chemical Structure

(+)-Bicuculline Chemical Structure

CAS No. 485-49-4

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(+)-Bicuculline Related Products

Biological Activity

Description (+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
Targets
GABAA receptor [1]
2 μM
In vitro
In vitro (+)-Bicuculline (1-100μM) dose-dependently inhibits the Cl- conductance generated by 40 μM GABA. (+)-Bicuculline also inhibits the agonist action of GABA at 40 μM at α1β2γ2L receptors. (+)-Bicuculline at 1 and 3 μM increases GABA EC50 values 1.6 times (41.0-67.0 μM) and 3.6 times (36.1-129.0 μM), respectively. Atα1β2γ2L GABAA receptors, (+)-bicuculline displays the general property of the competitive antagonist, producing a parallel shift of GABA concentration-effect curves and having no effect on the maximal response of GABA. [1] In addition to being a potent GABAA receptor antagonist, (+)-bicuculine also blocks Ca2+-activated potassium channels. [2]

Chemical Information & Solubility

Molecular Weight 367.35 Formula

C20H17NO6
CAS No. 485-49-4 SDF Download (+)-Bicuculline SDF
Smiles CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 73 mg/mL ( (198.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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