Home Metabolism P450 (e.g. CYP17) inhibitor Stiripentol For research use only.

Stiripentol

Synonyms: BCX2600

Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.

Stiripentol Chemical Structure

Stiripentol Chemical Structure

CAS No. 49763-96-4

Purity & Quality Control

Stiripentol Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05735951 Recruiting
Chronic Renal Insufficiency
Biocodex
 July 24 2023 Phase 1
NCT05419180 Unknown status
Pharmacoresistant Focal Epilepsies
Biocodex
 October 13 2022 Phase 4
NCT03819647 Completed
Primary Hyperoxaluria
Biocodex
 May 21 2019 Phase 2

Chemical Information & Solubility

Molecular Weight 234.29 Formula

C14H18O3
CAS No. 49763-96-4 SDF --
Smiles CC(C)(C)C(C=CC1=CC2=C(C=C1)OCO2)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 47 mg/mL ( (200.6 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 47 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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