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Segesterone acetate

Name: Segesterone acetate
Brand: Selleck Chemicals
SKU: E0937
Rating: 5 (1 reviews)

Synonyms: Nestoron, ST-1435

Catalog No.E0937 Purity:99.96%

Segesterone acetate (Nestoron, ST-1435) is a synthetic progestin that binds to the progesterone receptor with EC50 of 50.3 nM.

Segesterone acetate Chemical Structure

CAS No. 7759-35-5

Purity & Quality Control

Batch: E093701 DMSO]74 mg/mL]false]Ethanol]37 mg/mL]false]Water]Insoluble]false Purity: 99.96%

99.96

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Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description

Segesterone acetate (Nestoron, ST-1435) is a synthetic progestin that binds to the progesterone receptor with EC50 of 50.3 nM.

Targets

progesterone receptor ^[1]
(In the progestational assay)

50.3 nM(EC50)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT03452111	Active not recruiting	Healthy\|Men\|Male Contraception	Health Decisions\|Population Council\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	October 25 2018	Phase 2
NCT02994602	Completed	Healthy Men\|Male Contraception\|Healthy Women\|Product Transference	Health Decisions\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center\|University of Washington\|Population Council	January 2017	Phase 1
NCT00891228	Completed	Contraception	Health Decisions\|Population Council\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	May 2009	Phase 1

References

[1] Kumar N, et al. Steroids. 2000 Oct-Nov;65(10-11):629-36.

Chemical Information & Solubility

Molecular Weight	370.48	Formula	C₂₃H₃₀O₄
CAS No.	7759-35-5	SDF	--
Smiles	CC(=O)OC1(C(C)=O)C(=C)CC2C3CCC4=CC(=O)CCC4C3CCC12C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 74 mg/mL ( (199.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 37 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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