Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Elacestrant (RAD1901) Dihydrochloride For research use only.

Elacestrant (RAD1901) Dihydrochloride

Elacestrant (RAD1901) Dihydrochloride is an orally available selective estrogen receptor degrader (SERD) with IC50 of 48 nM and 870 nM for ERα and ERβ, respectively.

Elacestrant (RAD1901) Dihydrochloride Chemical Structure

Elacestrant (RAD1901) Dihydrochloride Chemical Structure

CAS No. 1349723-93-8

Purity & Quality Control

Batch: S962901 DMSO]100 mg/mL]false]Water]25 mg/mL]false]Ethanol]6 mg/mL]false Purity: 99.96%
99.96

Elacestrant (RAD1901) Dihydrochloride Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Elacestrant (RAD1901) Dihydrochloride is an orally available selective estrogen receptor degrader (SERD) with IC50 of 48 nM and 870 nM for ERα and ERβ, respectively.
Targets
ERα [1] ERβ [1]
48 nM 870 nM
In vitro
In vitro

Elacestrant (RAD1901) Dihydrochloride is a selective estrogen receptor degradation (SERD), which inhibits expression of ERα and ERβ in cultured breast tumor cell lines, thus inhibits the cell proliferation in a dose-dependent manner.[1]
Cell Research Cell lines MCF-7 cells
Concentrations 0.5-10 μM
Incubation Time 48 h
Method

ERα expression in MCF-7 cells in the presence of vehicle (0.1% DMSO), E2 (1 nmol/l), or RAD1901 (10 μmol/l to 0.5 nmol/l)  for 48 h. Levels of ERα receptor expression are expressed as percent of vehicle control.

Chemical Information & Solubility

Molecular Weight 531.56 Formula

C30H40Cl2N2O2
CAS No. 1349723-93-8 SDF --
Smiles CCNCCC1=CC=C(C=C1)CN(CC)C2=C(C=CC(=C2)OC)C3CCC4=C(C3)C=CC(=C4)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (188.12 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 25 mg/mL

Ethanol : 6 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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