Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Liquiritigenin For research use only.

Liquiritigenin

Synonyms: 4',7-Dihydroxyflavanone

Liquiritigenin (4',7-Dihydroxyflavanone), the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.

Liquiritigenin Chemical Structure

Liquiritigenin Chemical Structure

CAS No. 578-86-9

Purity & Quality Control

Batch: S392901 DMSO]51 mg/mL]false]]]false]]]false Purity: 99.91%
99.91

Liquiritigenin Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Liquiritigenin (4',7-Dihydroxyflavanone), the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.
Targets
ERβ [2] VEGF [3]
In vitro
In vitro Liquiritigenin-treated murine osteoblastic MC3T3-E1 cells shows an increased alkaline phosphatase activity and enhances phosphorylation of Smad1/5 compared with untreated cells. Moreover, liquiritigenin inhibits osteoclast differentiation, its bone-resorption activity through slightly decreases the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and inhibitor of nuclear factor kappa B-α ; however, the phosphorylation of Akt and p38 slightly increase in bone marrow-derived osteoclasts. The expression levels of the osteoclast marker proteins nuclear factor of activated T-cell cytoplasmic-1, Src, and cathepsin K diminish. Liquiritigenin is shown to exert the following pharmacological effects: increased cell growth, increased alkaline phosphatase activity, promotion of collagen synthesis, and the mineralization of osteoblastic MC3T3-E1 cells[1]. Liquiritigenin inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signaling pathway in HeLa cells[2].
Cell Research Cell lines Murine osteoblastic MC3T3-E1 cells
Concentrations 0-100 μM
Incubation Time 72 h
Method Cells seeded in 96-well cell culture plates are incubated with the Cell Counting Kit-8 for 1 h, and then the absorbance at 450nm is measured with a microplate reader.
In Vivo
In vivo Liquiritigenin inhibits the growth of tumors in nude mice originating from human cervical cancer cell line HeLa cells, and reduces angiogenesis in a dose dependent manner[2]. Liquiritigenin effectively reduces the levels of pro-inflammatory cytokines and the expressions of p-p65NF-κB and p-IκBα. Furthermore, liquiritigenin preconditioning could down-regulate the immobility time in tail suspension test (TST), forced swimming test (FST) and up-regulate BDNF and TrkB contents in hippocampus. Thus, liquiritigenin has antidepressant activity that might be attributed to its anti-inflammatory property and BDNF/TrkB signaling pathway[4].
Animal Research Animal Models nude BALB/c mice.
Dosages 10, 20, 40 mg/kg
Administration intragastrically
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01199250 Not yet recruiting
Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer
Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation
 January 2100 --
NCT04662164 Withdrawn
Type 2 Diabetes Patients
Shanghai HEP Pharmaceutical Co. Ltd.
 December 2025 Phase 1|Phase 2
NCT06177132 Not yet recruiting
Vestibular Disorder
University Hospital Ghent|University Ghent
 November 2025 Not Applicable
NCT03277170 Not yet recruiting
Asthma; Status|Asthma in Children|Asthma Acute|Asthma Attack|Acute Asthma Exacerbation
Vanderbilt University Medical Center
 September 1 2025 Phase 2

Chemical Information & Solubility

Molecular Weight 256.25 Formula

C15H12O4
CAS No. 578-86-9 SDF Download Liquiritigenin SDF
Smiles C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (199.02 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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