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Cholesterol

Name: Cholesterol
Brand: Selleck Chemicals
SKU: S4154
Rating: 5 (9 reviews)

Synonyms: Cholesterin

Catalog No.S4154 Purity:99.6%

Cholesterol(Cholesterin) is the principal sterol of all higher animals required to build and maintain membranes.

Cholesterol Chemical Structure

CAS No. 57-88-5

Purity & Quality Control

Batch: Purity: 99.6%

99.6

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Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description	Cholesterol(Cholesterin) is the principal sterol of all higher animals required to build and maintain membranes.

In vitro
In vitro	Cholesterol serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. It modulates membrane fluidity over the range of physiological temperatures. The hydroxyl group on cholesterol interacts with the polar head groups of the membrane phospholipids and sphingolipids, while the bulky steroid and the hydrocarbon chain are embedded in the membrane, alongside the nonpolar fatty-acid chain of the other lipids. Through the interaction with the phospholipid fatty-acid chains, cholesterol increases membrane packing, which reduces membrane fluidity. The structure of the tetracyclic ring of cholesterol contributes to the decreased fluidity of the cell membrane as the molecule is in a trans conformation making all but the side chain of cholesterol rigid and planar. In this structural role, cholesterol reduces the permeability of the plasma membrane to neutral solutes, protons, and sodium ions.

In Vivo
In vivo	Cholesterol is recycled. The liver excretes it in a non-esterified form (via bile) into the digestive tract. Typically about 50% of the excreted cholesterol is reabsorbed by the small bowel back into the bloodstream.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT01037387	Recruiting	Chronic Obstructive Pulmonary Disease\|Hypercapnic	Hospital Universitario La Paz	December 2025	Phase 4
NCT06159543	Not yet recruiting	Hyperglycemia\|Dyslipidemias\|Insulin Resistance\|Inflammation\|Oxidative Stress	Loma Linda University\|National Mango Board	September 2024	Not Applicable
NCT06405880	Not yet recruiting	Cardiovascular Risk Factors\|Blood Pressure\|Cardiovascular Disease\|Diabetes\|Dyslipidemia	University of Alberta	September 2024	Not Applicable

Chemical Information & Solubility

Molecular Weight	386.65	Formula	C₂₇H₄₆O
CAS No.	57-88-5	SDF	Download Cholesterol SDF
Smiles	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Ethanol : 6.25 mg/mL

DMSO : 0.03 mg/mL ( (0.07 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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