Home Endocrinology & Hormones Adrenergic Receptor antagonist S(-)-Propranolol hydrochloride For research use only.

S(-)-Propranolol hydrochloride

Synonyms: Hemangeol, Inderal

(S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

S(-)-Propranolol hydrochloride Chemical Structure

S(-)-Propranolol hydrochloride Chemical Structure

CAS No. 4199-10-4

Purity & Quality Control

S(-)-Propranolol hydrochloride Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description (S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.
In vitro
In vitro

Propranolol, a non-selective β1 and β2 adrenergic blocker, has no effect on the proliferation of neonatal mouse cardiac fibroblasts (NMCFs).[2]
Cell Research Cell lines neonatal mice cardiomyocytes (NMCMs)
Concentrations 10, 20, 40, 50, and 100 μM
Incubation Time 6, 12, 18, and 24 h
Method

In vitro, the neonatal mice cardiomyocytes (NMCMs) are treated with different drugs of different concentration, including isoproterenol (0, 1, 2.5, 5, 10, 20, and 50 μM); amiodarone (0, 1, 2.5, 5, 10, 20, and 50 μM); metoprolol (0, 10, 20, 30, 50, 100, 150, and 200 μM); propranolol (0, 10, 20, 40, 50, and 100 μM); lidocaine (0, 1, 2.5, 5, 10, 20, and 50 μM); verapamil(0, 1, 2.5, 5, 10, 20, and 50 μM);ivabradine (0, 1, 2, 3, 5, 10, and 20 μM). And the concentrations of drugs that promote CMs proliferation most significantly are chosen for subsequent experiments, including isoproterenol (10 μM), amiodarone (5 μM), metoprolol (20 μM), propranolol (20 μM), lidocaine (5 μM), verapamil (2.5 μM), ivabradine (3 μM) for NMCMs, NMCFs, and hPSC-CM.
In Vivo
In vivo

Propranolol, an anti-arrhythmic drugs, consistently reduces the heart rates of adult mice by approximately 10%-20%, whereas isoproterenol has the opposite effect.[2]
Animal Research Animal Models 1-day-old neonatal mice; 12-week-old adult mice
Dosages 10 mg/kg/d
Administration s.c.; ALZET Osmotic Pumps

Chemical Information & Solubility

Molecular Weight 295.8 Formula

C16H22ClNO2
CAS No. 4199-10-4 SDF --
Smiles Cl.CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 59 mg/mL ( (199.45 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 59 mg/mL

Ethanol : 20 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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