Home Endocrinology & Hormones Estrogen/progestogen Receptor modulator Raloxifene For research use only.

Raloxifene

Synonyms: Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129

Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.

Raloxifene Chemical Structure

Raloxifene Chemical Structure

CAS No. 84449-90-1

Purity & Quality Control

Batch: S578101 DMSO]95 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 98.47%
98.47

Raloxifene Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.
Targets
ER [1]
(Cell-free assay)
5.7 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01973738 Unknown status
Selective Estrogen Receptor Modulator
Toshihiko Kono|Tomidahama Hospital
 January 2012 --
NCT02977949 Unknown status
Selective Estrogen Receptor Modulator (SERM)
Toshihiko Kono|Tomidahama Hospital
 January 2012 --
NCT01573637 Completed
Schizophrenia in Post Menopausal Women
Fundació Sant Joan de Déu|Hospital Sant Joan de Deu|Parc Sanitari Sant Joan de Déu|Stanley Medical Research Institute
 July 2011 Phase 3

Chemical Information & Solubility

Molecular Weight 473.58 Formula

C28H27NO4S
CAS No. 84449-90-1 SDF --
Smiles C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 95 mg/mL ( (200.59 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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