Panitumumab (anti-EGFR)

Synonyms: ABX-EGF

Catalog No.A2018 Purity:99%

Panitumumab (anti-EGFR, ABX-EGF) is a recombinant, fully human IgG2 monoclonal antibody that binds to the epidermal growth factor receptor (EGFR).

Selleck's Panitumumab (anti-EGFR) has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 7.09 mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective EGFR Inhibitors

Name	Citation	EGFR/ErbB1	HER2/ErbB2	ErbB3	ErbB4	mutant EGFR	Others
Saracatinib (AZD0530)	283	+++					c-Src,LCK,c-YES
Canertinib (CI-1033)	46	++++	+++
AG-490	127	+					JAK2 (V617F)
CP-724714	108		++
WZ4002	34	++++
Sapitinib (AZD8931)	46	+++	+++	+++
CUDC-101	22	+++	++				HDAC,HDAC1,HDAC6
AG-1478	96	+++
PD153035 HCl	16	++++
Pelitinib (EKB-569)	11	+	+				Src,MEK/ERK,Raf
AEE788 (NVP-AEE788)	13	++++	+++		+		c-Abl,FLT1,c-Fms
AC480 (BMS-599626)	10	++	++		+
AP26113-analog (ALK-IN-1)	4					++	ALK,IGF1R,INSR
WZ3146	2	++++
Allitinib tosylate	16	++++	+++		++++
Rociletinib (CO-1686)	36	++
Varlitinib	8	+++	++++
Icotinib (BPI-2009H)	8	+++
TAK-285	4	++	++		+		MEK1,Aurora B,LCK
WHI-P154	11	+++					VEGFR,Src,JAK3
Daphnetin	4	+					PKA,PKC
PD168393	5	++++
CNX-2006	2	++				++
Tyrphostin 9	1	+					PDGFR
AG-18	1	+
4-AMino-1-phenylpyrazolo[3,4-d]pyriMidine	0	+
AST-1306	0	++++	+++		++++
ErbB2 inhibitor	0		+		+
Tuxobertinib (BDTX-189)	2	++++	++++				RIPK2,BLK
Epertinib hydrochloride	0	++++	+++		+++
JND3229	0	+++				++	EGFR C797S
BI-4020	1					++++
Tyrphostin AG-528	0	+	+
AG 556	0	+
Canertinib dihydrochloride	8	+++	+++
EGFR Inhibitor	2	++					Microtubules
SU5214	0	+					VEGFR2
RG 13022	0	+
TQB3804	0					++++
zipalertinib (TAS6417)	3	+++			+++	++++	TXK,BMX
Pyrotinib dimaleate	4	++	++
PD153035	14	++++
AG 494	0	+
AG 555	0	+
Theliatinib (HMPL-309)	0	+++				++
Avitinib (Abivertinib)	2					++++	JAK3,BTK
Lazertinib	6	++++				++++	Del19,L85R
Lifirafenib (BGB-283)	6	++				+	WT A-RAF,C-RAF (Y340/341D),BRAF(V600E)
Nazartinib (EGF816)	6	++				++
Zorifertinib (AZD3759)	6	++++
CL-387785 (EKI-785)	4	++++
Poziotinib	33	+++	+++		++
AZ5104	4	++++			+++		BLK,ACK1,BRK
AV-412 free base	0	++++	++			++++
HER2-Inhibitor-1		✔
WZ8040	✔
Genistein	✔					topo II
BDTX-1535	✔
Falnidamol	✔
BLU-945	✔
Sunvozertinib (DZD9008)	✔
CH7233163	✔
Licochalcone D	✔					PARP,Caspase,Met
Alflutinib (Furmonertinib) mesylate	✔					CYP3A4
(Rac)-JBJ-04-125-02	✔
Tyrphostin AG30 (AG30)	✔
AG-1557	✔
AG99	✔
MTX-211	✔					PI3K
RG14620	✔					ABCG2
Almonertinib (HS-10296)					✔
Cyasterone	✔
Norcantharidin	✔					c-Met
Naquotinib(ASP8273)	✔
EAI045					✔
Olmutinib (BI 1482694)	✔					BTK
Butein	✔
Chrysophanic Acid	✔					mTOR
EGCG ((-)-Epigallocatechin Gallate)		✔				FASN,DNMT,telomerase

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Panitumumab (anti-EGFR, ABX-EGF) is a recombinant, fully human IgG2 monoclonal antibody that binds to the epidermal growth factor receptor (EGFR).

References
[1] Wells A Messersmith, et al. Clin Cancer Res . 2007 Aug 15;13(16):4664-6.

References

[1] Wells A Messersmith, et al. Clin Cancer Res . 2007 Aug 15;13(16):4664-6.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	339177-26-3
Molecular Weight	144 kD
Isotype	Human IgG2
Source	CHO cells
Sterility	0.2 μM filtered
Formulation	PBS Buffer, PH 7.4
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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