Home Protein Tyrosine Kinase EGFR inhibitor HS-10296 hydrochloride For research use only.

HS-10296 hydrochloride

Synonyms: Almonertinib (hydrochloride), HS-10296 HCl

HS-10296 hydrochloride(Almonertinib (hydrochloride), HS-10296 HCl) is an irreversible, third-generation inhibitor of EGFR tyrosine kinase that demonstrates high selectivity for EGFR-sensitizing mutations, T790M resistance mutation. It exhibits inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37 nM, 0.29 nM, and 0.21 nM, respectively. It also exhibits anti-tumor activity.

HS-10296 hydrochloride Chemical Structure

HS-10296 hydrochloride Chemical Structure

CAS No. 2134096-03-8

Purity & Quality Control

Batch: E488601 Water]25 mg/mL]false]DMSO]13 mg/mL]false]Ethanol]Insoluble]false Purity: 97.62%
97.62

HS-10296 hydrochloride Related Products

Signaling Pathway

EGFR Signaling Pathways

EGFR Signaling Pathway

Biological Activity

Description HS-10296 hydrochloride(Almonertinib (hydrochloride), HS-10296 HCl) is an irreversible, third-generation inhibitor of EGFR tyrosine kinase that demonstrates high selectivity for EGFR-sensitizing mutations, T790M resistance mutation. It exhibits inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37 nM, 0.29 nM, and 0.21 nM, respectively. It also exhibits anti-tumor activity.

Chemical Information & Solubility

Molecular Weight 562.11 Formula

C30H35N7O2.ClH
CAS No. 2134096-03-8 SDF Download HS-10296 hydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

Water : 25 mg/mL

DMSO : 13 mg/mL ( (23.12 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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