Home Protein Tyrosine Kinase EGFR inhibitor - P450 (e.g. CYP17) activator Alflutinib (Furmonertinib) mesylate For research use only.

Alflutinib (Furmonertinib) mesylate

Synonyms: AST2818 mesylate

Alflutinib (Furmonertinib) mesylate is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Alflutinib (AST2818), primarily metabolized by CYP3A4, is also a potent CYP3A4 inducer with EC50 of 0.25 μM.

Alflutinib (Furmonertinib) mesylate Chemical Structure

Alflutinib (Furmonertinib) mesylate Chemical Structure

CAS No. 2130958-55-1

Purity & Quality Control

Batch: S686801 DMSO]20 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.99%
99.99

Alflutinib (Furmonertinib) mesylate Related Products

Signaling Pathway

EGFR Signaling Pathways

EGFR Signaling Pathway

Biological Activity

Description Alflutinib (Furmonertinib) mesylate is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Alflutinib (AST2818), primarily metabolized by CYP3A4, is also a potent CYP3A4 inducer with EC50 of 0.25 μM.
Targets
EGFR [1] CYP3A4 [1]
(Cell-free assay)
0.25 μM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05364073 Recruiting
Non-Small Cell Lung Cancer (NSCLC)|Metastatic Non-Small Cell Lung Cancer|Advanced Non-Small Cell Lung Cancer|HER2 Exon 20 Mutations|EGFR Exon 20 Mutations|EGFR Uncommon Mutations Including G719X and S768I
ArriVent BioPharma Inc.
 June 30 2022 Phase 1
NCT03941340 Completed
Healthy Male Volunteers
Allist Pharmaceuticals Inc.
 April 8 2019 Phase 1
NCT03926182 Completed
Healthy Male Volunteers
Allist Pharmaceuticals Inc.
 February 19 2019 Phase 1
NCT03452592 Unknown status
Advanced NSCLC Patients With T790M
Allist Pharmaceuticals Inc.
 April 30 2018 Phase 2
NCT03127449 Unknown status
Advanced NSCLC
Allist Pharmaceuticals Inc.
 June 1 2017 Not Applicable

Chemical Information & Solubility

Molecular Weight 664.7 Formula

C29H35F3N8O5S
CAS No. 2130958-55-1 SDF --
Smiles CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(N=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OCC(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 20 mg/mL ( (30.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Alflutinib (Furmonertinib) mesylate | Alflutinib (Furmonertinib) mesylate supplier | purchase Alflutinib (Furmonertinib) mesylate | Alflutinib (Furmonertinib) mesylate cost | Alflutinib (Furmonertinib) mesylate manufacturer | order Alflutinib (Furmonertinib) mesylate | Alflutinib (Furmonertinib) mesylate distributor