Home Protein Tyrosine Kinase EGFR inhibitor BDTX-1535 For research use only.

BDTX-1535

Synonyms: EGFR-IN-76

BDTX-1535 (EGFR-IN-76) is an orally available, highly potent, selective, and irreversible EGFR inhibitor that can penetrate the blood-brain barrier, with the potential to treat Glioblastoma or Non-Small Cell Lung Cancer.

BDTX-1535 Chemical Structure

BDTX-1535 Chemical Structure

CAS No. 2607829-38-7

Purity & Quality Control

Batch: E147801 DMSO]100 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.02%
99.02

BDTX-1535 Related Products

Signaling Pathway

EGFR Signaling Pathways

EGFR Signaling Pathway

Biological Activity

Description BDTX-1535 (EGFR-IN-76) is an orally available, highly potent, selective, and irreversible EGFR inhibitor that can penetrate the blood-brain barrier, with the potential to treat Glioblastoma or Non-Small Cell Lung Cancer.
Targets
EGFR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06072586 Recruiting
High Grade Glioma
St. Joseph''s Hospital and Medical Center Phoenix|Ivy Brain Tumor Center|Barrow Neurological Institute
 October 18 2023 Early Phase 1
NCT05256290 Recruiting
Non-Small Cell Lung Cancer|Advanced Non-Small Cell Squamous Lung Cancer|Metastatic Lung Non-Small Cell Carcinoma|Metastatic Lung Cancer|NSCLC|Advanced Lung Carcinoma|Epidermal Growth Factor Receptor C797S|Epidermal Growth Factor Receptor G719X|EGF-R Positive Non-Small Cell Lung Cancer|EGFR-TKI Resistant Mutation
Black Diamond Therapeutics Inc.
 March 31 2022 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 561.05 Formula

C30H30ClFN6O2
CAS No. 2607829-38-7 SDF Download BDTX-1535 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (178.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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