Home Epigenetics Epigenetic Reader Domain inhibitor ODM-207 For research use only.

ODM-207

ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.

ODM-207 Chemical Structure

ODM-207 Chemical Structure

CAS No. 1801503-93-4

Purity & Quality Control

Batch: E109501 DMSO]38 mg/mL]false]Ethanol]4 mg/mL]false]Water]Insoluble]false Purity: 99.80%
99.80

ODM-207 Related Products

Signaling Pathway

Epigenetic Reader Domain Signaling Pathways

Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.
Targets
BET [1]
In vitro
In vitro

ODM-207 is a potent DNA damage responses (DDR) targeted drugs with an IC50 of 2.12 μM. RNAi inhibition of RAD52-dependent HR potentiates the efficacy of a novel BETi ODM-207 in cutaneous apocrine sweat gland carcinoma patient derived tumor cells .[2]
Cell Research Cell lines Cutaneous apocrine sweat gland carcinoma patient derived tumor cells
Concentrations 500 nM
Incubation Time 48 h
Method

Cells are exposed to 500 nM ODM-207 for 48 hours. Analysis of RNAi effects on cell viability are quantified on basis of cell counts, while the analysis of RNAi induced accumulation of DNA damage is performed with automated quantification of antibody detected nuclear γH2AX foci per cell.

Chemical Information & Solubility

Molecular Weight 375.42 Formula

C22H21N3O3
CAS No. 1801503-93-4 SDF --
Smiles COC1=C(C=C2C=C(C)C(=O)N(CC3=CC=CC=N3)C2=C1)C4=C(C)ON=C4C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 38 mg/mL ( (101.21 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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