Home Epigenetics Epigenetic Reader Domain inhibitor - Histone Acetyltransferase inhibitor Histone Acetyltransferase Inhibitor II For research use only.

Histone Acetyltransferase Inhibitor II

Synonyms: HAT Inhibitor II

Histone Acetyltransferase Inhibitor II (HAT Inhibitor II, compound 2c) is a potent, selective and cell-permeable p300 histone acetyltransferase (HAT) inhibitor with IC50 of 5 μM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.

Histone Acetyltransferase Inhibitor II Chemical Structure

Histone Acetyltransferase Inhibitor II Chemical Structure

CAS No. 932749-62-7

Purity & Quality Control

Batch: S116101 DMSO]93 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.89%
99.89

Histone Acetyltransferase Inhibitor II Related Products

Signaling Pathway

Epigenetic Reader Domain Signaling Pathways

Epigenetic Reader Domain Signaling Pathway

Biological Activity

Description

Histone Acetyltransferase Inhibitor II (HAT Inhibitor II, compound 2c) is a potent, selective and cell-permeable p300 histone acetyltransferase (HAT) inhibitor with IC50 of 5 μM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.
Targets
p300 [1]
(Cell-free assay)
5 μM

Chemical Information & Solubility

Molecular Weight 464.15 Formula

C20H16Br2O3
CAS No. 932749-62-7 SDF --
Smiles OC1=C(Br)C=C(C=C1)\C=C2/CCC\C(=C/C3=CC(=C(O)C=C3)Br)C2=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 93 mg/mL ( (200.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Histone Acetyltransferase Inhibitor II | Histone Acetyltransferase Inhibitor II supplier | purchase Histone Acetyltransferase Inhibitor II | Histone Acetyltransferase Inhibitor II cost | Histone Acetyltransferase Inhibitor II manufacturer | order Histone Acetyltransferase Inhibitor II | Histone Acetyltransferase Inhibitor II distributor