Home Epigenetics Epigenetic Reader Domain inhibitor UNC669 For research use only.

UNC669

UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4.

UNC669 Chemical Structure

UNC669 Chemical Structure

CAS No. 1314241-44-5

Purity & Quality Control

Batch: S737301 Ethanol]68 mg/mL]false]DMSO]11 mg/mL]false]Water]Insoluble]false Purity: 99.93%
99.93

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Biological Activity

Description UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4.
Features MBT-selective chemical probe.
Targets
L3MBTL1 [1] L3MBTL3 [1] L3MBTL4 [1]
6 μM 35 μM 69 μM
In vitro
In vitro UNC669, as a low μM binder of L3MBTL1, provides new directions for optimization of MBT inhibitors to improve potency and selectivity. [1]

Chemical Information & Solubility

Molecular Weight 338.24 Formula

C15H20BrN3O
CAS No. 1314241-44-5 SDF Download UNC669 SDF
Smiles C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CN=C3)Br
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 68 mg/mL

DMSO : 11 mg/mL ( (32.52 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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