Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S8265	GSK6853	GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.	Selective	BRPF1, pIC50: 8.1
S5916	GSK 5959	GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.	Selective	BRPF1, pIC50: 7.1; BRPF2, pIC50: 5.2; BRPF3, pIC50: 4.5
S7906	PFI-4	PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.	Selective	BRPF1, IC50: 80 nM; BRPF2, IC50: 7.9 μM; BRPF3, IC50: >10μM
S7681	OF-1	OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with K_d of 100 nM and 500 nM, respectively.	Selective	BRPF1B, Kd: 100 nM; BRPF2, Kd: 500 nM

BRPF Selective Inhibitors