ODM-207

Catalog No.E1095 Batch:E109501

Technical Data

Formula	C₂₂H₂₁N₃O₃
Molecular Weight	375.42	CAS No.	1801503-93-4
Solubility (25°C)*	In vitro	DMSO	38 mg/mL (101.21 mM)
		Ethanol	4 mg/mL (10.65 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.

Targets

BET ^[1]

In vitro

ODM-207 is a potent DNA damage responses (DDR) targeted drugs with an IC50 of 2.12 μM. RNAi inhibition of RAD52-dependent HR potentiates the efficacy of a novel BETi ODM-207 in cutaneous apocrine sweat gland carcinoma patient derived tumor cells .^[2]

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines Cutaneous apocrine sweat gland carcinoma patient derived tumor cells Concentrations 500 nM Incubation Time 48 h Method Cells are exposed to 500 nM ODM-207 for 48 hours. Analysis of RNAi effects on cell viability are quantified on basis of cell counts, while the analysis of RNAi induced accumulation of DNA damage is performed with automated quantification of antibody detected nuclear γH2AX foci per cell.

Cell Assay:^{^[2]}

Cell lines
Cutaneous apocrine sweat gland carcinoma patient derived tumor cells
Concentrations
500 nM
Incubation Time
48 h
Method
Cells are exposed to 500 nM ODM-207 for 48 hours. Analysis of RNAi effects on cell viability are quantified on basis of cell counts, while the analysis of RNAi induced accumulation of DNA damage is performed with automated quantification of antibody detected nuclear γH2AX foci per cell.

References

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SHIPPING AND STORAGE
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