Home Neuronal Signaling Adrenergic Receptor inhibitor Nebivolol For research use only.

Nebivolol

Synonyms: Bystolic,R 065824

Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

Nebivolol Chemical Structure

Nebivolol Chemical Structure

CAS No. 118457-14-0

Purity & Quality Control

Batch: S573901 DMSO]88 mg/mL]false]]]false]]]false Purity: 98%
98

Nebivolol Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06004453 Recruiting
Heart Failure
Novartis Pharmaceuticals|Novartis
 April 4 2023 --
NCT04888728 Completed
Idiopathic Pulmonary Fibrosis
Daewoong Pharmaceutical Co. LTD.
 June 30 2021 Phase 1
NCT03847350 Completed
Essential Hypertension
A.Menarini Asia-Pacific Holdings Pte Ltd
 July 1 2015 --
NCT01885988 Unknown status
Erectile Dysfunction
Martin M. Miner MD|Forest Laboratories|The Miriam Hospital
 March 2013 Phase 4
NCT01057251 Completed
Hypertension
Forest Laboratories
 March 2010 Phase 4

Chemical Information & Solubility

Molecular Weight 405.43 Formula

C22H25F2NO4
CAS No. 118457-14-0 SDF --
Smiles C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 88 mg/mL ( (217.05 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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