Home Neuronal Signaling Adrenergic Receptor antagonist Metoprolol For research use only.

Metoprolol

Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.

Metoprolol Chemical Structure

Metoprolol Chemical Structure

CAS No. 51384-51-1

Purity & Quality Control

Metoprolol Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
Targets
β1-adrenergic receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06004453 Recruiting
Heart Failure
Novartis Pharmaceuticals|Novartis
 April 4 2023 --
NCT05368831 Completed
Healthy Volunteers
NorthSea Therapeutics B.V.
 July 19 2022 Phase 1
NCT05171985 Unknown status
COVID-19 Pneumonia|Atrial Fibrillation
Tanta University
 January 2022 Not Applicable
NCT04842981 Terminated
Arthritis Rheumatoid|Interaction
University of Southern Denmark|Odense University Hospital|Hospital of South West Jutland|King Christian X´Hospital for Rheumatic Diseases|Sygehus Lillebaelt|Odense Patient Data Explorative Network
 May 25 2021 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 267.36 Formula

C15H25NO3
CAS No. 51384-51-1 SDF --
Smiles CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 53 mg/mL ( (198.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 53 mg/mL

Ethanol : 53 mg/mL


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In vivo
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