Choose Your Country or Region

Leronlimab (anti-CCR5)

Synonyms: PRO 140; Vyrologix

Catalog No.A2040 Purity:99%

Leronlimab (anti-CCR5) （PRO 140; Vyrologix）is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.

Click to purchase the isotype control of Leronlimab (anti-CCR5)

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 3.19mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective CCR Inhibitors

Name	Citation	CCR	CCR1	CCR2	CCR3	CCR4	CCR5	CCR9	CCL	Others
SB-328437	0				++
INCB3344	4			++						mCCR2
RS504393	0			+
C-021	0					+
Vercirnon	0							+++
BX471	1		++++
PF-4136309	0			++
Vicriviroc maleate	1	+++					+++
RS-102895 Hydrochloride	0			+						human α1a receptor,human α1d receptor,5-HT1a receptor
RS102895	2			+
TAK-779	0	++++					++++			CXCR3
AZD2098	1					++
Adaptavir (DAPTA)	3	++++					++++
R243	✔
Perillaldehyde								✔	NRF2/HO1,ROS,AhR
Cenicriviroc			✔						HIV-2,HIV-1
Isuzinaxib (APX-115 free base)								✔	TNFα,IL-6,NOX2
SB-297006				✔
BMS-813160			✔
Bindarit								✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Leronlimab (anti-CCR5) （PRO 140; Vyrologix）is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.

In Vitro
In vitro	Leronlimab binds CCR5 in multiple breast cancer cell lines, reducing ligand-induced Ca^+ 2 signaling, invasion of TNBC into Matrigel, and transwell migration, also enhances the breast cancer (BCa) cell killing of the BCa chemotherapy reagent, doxorubicin.^[1]
Cell Research:	Equal numbers of cells were plated, and after 72 h of exposure to the drugs, cells were incubated with 1 mg/mL of MTT for 90 min. The reduced (insoluble and colored) formazan was dissolved in 0.04 N HCl acidified isopropanol and measured spectrophotometrically at 570 nm.

In Vitro

In vitro

Leronlimab binds CCR5 in multiple breast cancer cell lines, reducing ligand-induced Ca^+ 2 signaling, invasion of TNBC into Matrigel, and transwell migration, also enhances the breast cancer (BCa) cell killing of the BCa chemotherapy reagent, doxorubicin.^[1]

Cell Research:

Equal numbers of cells were plated, and after 72 h of exposure to the drugs, cells were incubated with 1 mg/mL of MTT for 90 min. The reduced (insoluble and colored) formazan was dissolved in 0.04 N HCl acidified isopropanol and measured spectrophotometrically at 570 nm.

In Vivo
In vivo	In xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis.^[1]
Animal Research	AnimalModels:Female NCI Athymic nu/nu nude mice injected with MB-MDA-231 cells expressing Luc2-eGFP Dosages:2 mg/mouse Administration:i.p.^[1]

In Vivo

In vivo

In xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis.^[1]

Animal Research

AnimalModels:Female NCI Athymic nu/nu nude mice injected with MB-MDA-231 cells expressing Luc2-eGFP
Dosages:2 mg/mouse
Administration:i.p.^[1]

References
[1] Jiao X, et al. Breast Cancer Res. 2021 Jan 23;23(1):11.

References

[1] Jiao X, et al. Breast Cancer Res. 2021 Jan 23;23(1):11.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	674782-26-4
Molecular Weight	146.7 KD
Isotype	Human IgG4
Application	Leronlimab (anti-CCR5)
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20 mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Tech Support

If you have any other enquiries, please leave a message.

* Indicates a Required Field

* Name Please enter your name.

* Email Please enter your email. Please enter a valid email address.

Phone

* Comments: Please write something to us.