Home Immunology & Inflammation CCR antagonist BMS-813160 For research use only.

BMS-813160

BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.

BMS-813160 Chemical Structure

BMS-813160 Chemical Structure

CAS No. 1286279-29-5

Purity & Quality Control

BMS-813160 Related Products

Signaling Pathway

CCR Signaling Pathways

CCR Signaling Pathway

Biological Activity

Description BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.
Targets
CCR2 [1] CCR5 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01752985 Terminated
Diabetic Kidney Disease
Bristol-Myers Squibb
 March 18 2013 Phase 2
NCT01049165 Completed
Accelerated Intimal Hyperplasia
Bristol-Myers Squibb
 February 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 484.64 Formula

C25H40N8O2
CAS No. 1286279-29-5 SDF --
Smiles CC(=O)NC1CC(CCC1N2CCC(C2=O)NC3=NC=NC4=CC(=NN43)C(C)(C)C)NC(C)(C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 97 mg/mL ( (200.14 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 97 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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