Home GPCR & G Protein CCR antagonist - HIV Protease inhibitor Vicriviroc maleate For research use only.

Vicriviroc maleate

Synonyms: SCH-417690 maleate, SCH-D maleate

Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.

Vicriviroc maleate Chemical Structure

Vicriviroc maleate Chemical Structure

CAS No. 599179-03-0

Purity & Quality Control

Batch: S349401 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]50 mg/mL]false Purity: 99.96%
99.96

Vicriviroc maleate Related Products

Signaling Pathway

CCR Signaling Pathways

CCR Signaling Pathway

Biological Activity

Description Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.
Targets
HIV-1 [1] CCR5 [1]
(in PK assays)
2.5 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03631407 Completed
Colorectal Neoplasms
Merck Sharp & Dohme LLC
 September 24 2018 Phase 2

Chemical Information & Solubility

Molecular Weight 649.7 Formula

C32H42F3N5O6
CAS No. 599179-03-0 SDF --
Smiles COCC(N1CCN(CC1C)C2(C)CCN(CC2)C(=O)C3=C(C)N=CN=C3C)C4=CC=C(C=C4)C(F)(F)F.OC(=O)\C=C/C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (153.91 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : 50 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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