Home GPCR & G Protein CCR antagonist Vercirnon For research use only.

Vercirnon

Synonyms: GSK-1605786, CCX-282, Traficet-EN

Vercirnon (GSK1605786A, CCX-282, Traficet-EN), an orally bioavailable, selective, and potent antagonist of CCR9, is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9.

Vercirnon Chemical Structure

Vercirnon Chemical Structure

CAS No. 698394-73-9

Purity & Quality Control

Vercirnon Related Products

Signaling Pathway

CCR Signaling Pathways

CCR Signaling Pathway

Biological Activity

Description Vercirnon (GSK1605786A, CCX-282, Traficet-EN), an orally bioavailable, selective, and potent antagonist of CCR9, is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9.
Targets
CCR9B [1]
(in the chemotaxis assays)		 CCR9A [1]
(in the chemotaxis assays)
2.6 nM 2.8 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01658605 Withdrawn
Colitis Ulcerative
GlaxoSmithKline
 February 2013 Phase 2
NCT01536418 Terminated
Crohn''s Disease
GlaxoSmithKline
 November 11 2011 Phase 3
NCT00540657 Completed
Celiac Disease
ChemoCentryx
 October 2007 Phase 2

Chemical Information & Solubility

Molecular Weight 444.93 Formula

C22H21ClN2O4S
CAS No. 698394-73-9 SDF --
Smiles CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NC2=CC=C(Cl)C=C2C(=O)C3=CC=[N](=O)C=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 45 mg/mL ( (101.13 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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