Icrucumab (Anti-VEGFR1 / FLT1)

Synonyms: iVR1

Catalog No.A2301 Purity:99%

Icrucumab (Anti-VEGFR1 / FLT1) is a humanized Anti-VEGFR-1 IgG1 monoclonal antibody, with potential anti-tumor and anti-metastatic agent. It also act as a therapeutic anti-angiogenic agent in different pathological contexts.

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 6.321mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective VEGFR Inhibitors

Name	Citation	VEGFR1	VEGFR2	VEGFR3	Others
Foretinib	93	+++	++++	++++	Met,Tie-2,RON
Cediranib (AZD2171)	66	+++	++++	++++	c-Kit,PDGFRβ,FGFR1
PD173074	120		+		FGFR1
Dovitinib (TKI-258)	49	+++	+++	+++	FLT3,c-Kit,FGFR1
Linifanib (ABT-869)	32	++++	++++	+	CSF-1R,FLT3,Kit
Vatalanib (PTK787) 2HCl	51	+	++	+	PDGFRβ,c-Kit,c-Fms
RAF265 (CHIR-265)	23		++		B-Raf
Motesanib Diphosphate (AMG-706)	12	++++	++++	+++	Kit,RET,PDGFR
Brivanib (BMS-540215)	9	+	++		FGFR1
MGCD-265 analog	12	++++	++++	++++	Met,RON,Tie-2
AEE788 (NVP-AEE788)	13	+	+		EGFR,HER2/ErbB2,c-Abl
ENMD-2076	8		+	++	FLT3,RET,Aurora A
OSI-930	7	+++	+++		CSF-1R,LCK,C-Raf
CYC116	10		++		Aurora A,Aurora B,FLT3
Ki8751	20		++++		c-Kit,PDGFRα
Telatinib	5		+++	++++	c-Kit,PDGFRα
KRN 633	6	+	+	+	PDGFRα,c-Kit,BTK
SAR131675	30			++
Apatinib (YN968D1) mesylate	23		++++		RET
BMS-794833	1		++		Met
Brivanib Alaninate (BMS-582664)	2	+	++		FGFR1
Golvatinib (E7050)	8		++		c-Met
Semaxanib (SU5416)	19		+
ZM 323881 HCl	17		++++
ZM 306416	13	+			Src,Abl
Sitravatinib (MGCD516)	3	+++	+++	++++	DDR2,EPHA3,Axl
BFH772	0		++++
BAW2881 (NVP-BAW2881)	2	+	+++	+	C-Raf-1,B-RAFV599E,c-Abl
SU5402	17		++		FGFR1,PDGFRβ
Dovitinib (TKI258) Lactate monohydrate	30	+++	+++	+++	FLT3,c-Kit,FGFR1
LY2874455	14		+++		FGFR2,FGFR1,FGFR4
SKLB1002	4		++
AZD2932	3		+++		PDGFRβ,Flt3,c-Kit

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Icrucumab (Anti-VEGFR1 / FLT1) is a humanized Anti-VEGFR-1 IgG1 monoclonal antibody, with potential anti-tumor and anti-metastatic agent. It also act as a therapeutic anti-angiogenic agent in different pathological contexts.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1024603-92-6
Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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