Home Protein Tyrosine Kinase VEGFR inhibitor - PDGFR inhibitor - c-Kit inhibitor SU14813 For research use only.

SU14813

Synonyms: SU 014813

SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.

SU14813 Chemical Structure

SU14813 Chemical Structure

CAS No. 627908-92-3

Purity & Quality Control

SU14813 Related Products

Signaling Pathway

VEGFR Signaling Pathways

VEGFR Signaling Pathway

Biological Activity

Description SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.
Targets
VEGFR1 [1]
(Cell-free assay)		 PDGFRβ [1]
(Cell-free assay)		 KIT [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)
2 nM 4 nM 15 nM 50 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00322517 Completed
Breast Neoplasms
Pfizer
 April 2006 Phase 2
NCT00982267 Completed
Neoplasms|Solid Tumors
Pfizer
 December 2003 Phase 1

Chemical Information & Solubility

Molecular Weight 442.48 Formula

C23H27FN4O4
CAS No. 627908-92-3 SDF --
Smiles CC1=C(NC(=C1C(=O)NCC(CN2CCOCC2)O)C)C=C3C4=C(C=CC(=C4)F)NC3=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 88 mg/mL ( (198.87 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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