Home Protein Tyrosine Kinase VEGFR inhibitor - c-Kit inhibitor - FLT3 inhibitor - Apoptosis related activator SU5614 For research use only.

SU5614

Synonyms: Chloro-SU5416, Chloro-Semaxanib

SU5614 (Chloro-SU5416, Chloro-Semaxanib) is a small molecule receptor tyrosine kinases (RTK) inhibitor of VEGFR-2, c-kit, and both wild-type and mutant FLT3. SU5614 reduces cell proliferation and induces apoptosis.

SU5614 Chemical Structure

SU5614 Chemical Structure

CAS No. 1055412-47-9

Purity & Quality Control

SU5614 Related Products

Signaling Pathway

VEGFR Signaling Pathways

VEGFR Signaling Pathway

Biological Activity

Description SU5614 (Chloro-SU5416, Chloro-Semaxanib) is a small molecule receptor tyrosine kinases (RTK) inhibitor of VEGFR-2, c-kit, and both wild-type and mutant FLT3. SU5614 reduces cell proliferation and induces apoptosis.
Targets
VEGFR-2 [1] c-Kit [1] FLT3 [1] RET [2]
(Cell-free assay)
170 nM

Chemical Information & Solubility

Molecular Weight 272.73 Formula

C15H13ClN2O
CAS No. 1055412-47-9 SDF --
Smiles CC1=CC(=C(N1)C=C2C3=C(C=CC(=C3)Cl)NC2=O)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 10 mg/mL ( (36.66 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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