Home Angiogenesis VEGFR inhibitor Taxifolin (Dihydroquercetin) For research use only.

Taxifolin (Dihydroquercetin)

Taxifolin, type I inhibitor for VEGFR-2 kinase, is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.

Taxifolin (Dihydroquercetin) Chemical Structure

Taxifolin (Dihydroquercetin) Chemical Structure

CAS No. 480-18-2

Purity & Quality Control

Taxifolin (Dihydroquercetin) Related Products

Signaling Pathway

VEGFR Signaling Pathways

VEGFR Signaling Pathway

Biological Activity

Description Taxifolin, type I inhibitor for VEGFR-2 kinase, is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
Targets
VEGFR2 kinase [4]
In vitro
In vitro Taxifolin is not mutagenic and low toxic compared to Qercetin. [1] It acts as a potential chemopreventive agent by regulating genes via an ARE-dependent mechanism. [2] Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner. [3]

Chemical Information & Solubility

Molecular Weight 304.25 Formula

C15H12O7
CAS No. 480-18-2 SDF Download Taxifolin (Dihydroquercetin) SDF
Smiles C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 61 mg/mL ( (200.49 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 61 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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