Home Protein Tyrosine Kinase CSF-1R inhibitor - Aurora Kinase inhibitor - VEGFR inhibitor - PDGFR inhibitor - c-Kit inhibitor Chiauranib For research use only.

Chiauranib

Synonyms: CS2164

Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.

Chiauranib Chemical Structure

Chiauranib Chemical Structure

CAS No. 1256349-48-0

Purity & Quality Control

Batch: E061601 DMSO]87 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 99.49%
99.49

Chiauranib Related Products

Signaling Pathway

CSF-1R Signaling Pathways

CSF-1R Signaling Pathway

Biological Activity

Description Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
Targets
c-Kit [1]
(Kinase inhibition assay)		 VEGFR2 [1]
(Kinase inhibition assay)		 CSF-1R [1]
(Kinase inhibition assay)		 Aurora B [1]
(Kinase inhibition assay)
4 nM 7 nM 7 nM 9 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05346601 Completed
Healthy Volunteers
Chipscreen Biosciences Ltd.|H & J CRO International Inc.
 June 2 2022 Phase 1
NCT02122809 Completed
Solid Tumors
Chipscreen Biosciences Ltd.
 February 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 435.5 Formula

C27H21N3O3
CAS No. 1256349-48-0 SDF --
Smiles COC1=CC2=C(C=C1)C(=CC=N2)OC3=CC4=C(C=C3)C(=CC=C4)C(=O)NC5=C(N)C=CC=C5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 87 mg/mL ( (199.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Chiauranib | Chiauranib supplier | purchase Chiauranib | Chiauranib cost | Chiauranib manufacturer | order Chiauranib | Chiauranib distributor