Golimumab (Anti-TNFSF2 / TNFa)

Synonyms: CNTO-148

Catalog No.A2892 Purity:99%

Golimumab (Anti-TNFSF2 / TNFa) is a human monoclonal antibody directed against the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) with immunosuppressive activity. MW: 146.94 KD.

Purity & Quality Control

Batch: A289201 Purity: 99% Protein concentration: 3.54mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective TNF-alpha Inhibitors

Name	Citation	TNF-α	TNF-alpha	Others
QNZ (EVP4593)	140	++++		NF-κB
JTE-607 Dihydrochloride	0	++++	++++	IL-1beta,IL-8,IL-6
PF-3644022	1	+		MK2
UCB-9260	0	+++	+++	NF-κB
MD2-TLR4-IN-1	0	+		TLR4,IL-6
R-7050	8	+		IL-1β
Resatorvid (TAK-242)	50	++++		TLR4,IL-6,NO
Apigenin-7-O-glucuronide	✔
UTL-5g	✔
Benpyrine racemate	✔
Amarogentin	✔		TAS2R1,AMPK
Stylopine	✔		IL-1β,NO,COX-2
Myrislignan	✔		iNOS,IL-6,NF-κB
NE 52-QQ57	✔		iNOS,IL-6,IL-1β
Falcarindiol	✔		IL-1β,IL-6,iNOS
Gardenoside	✔		NF-κB,P2X7 Receptor,IL-6
Cucurbitacin IIb	✔		JNK,STAT3,NF-κB
IQ 3	✔		IL-6,JNK3,JNK1
Isuzinaxib (APX-115 free base)	✔		IL-6,MCP-1/CCL2,NOX2
AUDA	✔		Smad3,TGF-β,IL-1β
CPI-1189	✔
Madecassic acid	✔		IL-1β,COX-2,iNOS
Homoplantaginin	✔		IL-6,IKKβ,NF-κB
2',5'-Dihydroxyacetophenone	✔		IL-6,NF-κB,ERK1/2
Forsythoside B	✔		IκB,NF-κB,IL-6
Mulberroside A	✔		ERK,NF-κB,Caspase-1
Ginsenoside Rb1	✔		TLR3,NF-κB,IRAK-1
Muscone	✔		IL-6,IL-1β,NLRP3 inflammasome
Shikonin	✔		NF-κB,Proteasome,chemokine receptor
Methylthiouracil	✔		IL-6,ERK1/2,NF-κB

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Golimumab (Anti-TNFSF2 / TNFa) is a human monoclonal antibody directed against the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) with immunosuppressive activity. MW: 146.94 KD.

References
[1] Shealy DJ, et al. MAbs. 2010;2(4):428-439.

References

[1] Shealy DJ, et al. MAbs. 2010;2(4):428-439.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	476181-74-5
Molecular Weight	146.94
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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