Home GPCR & G Protein Estrogen/progestogen Receptor antagonist - GPR antagonist G-1 (LNS 8801) For research use only.

G-1 (LNS 8801)

G-1 (LNS 8801) is a nonsteroidal and selective agonist of G protein-coupled receptor 30 (GPR30, G protein-coupled estrogen receptor 1, GPER) with Ki of 11 nM.

G-1 (LNS 8801) Chemical Structure

G-1 (LNS 8801) Chemical Structure

CAS No. 881639-98-1

Purity & Quality Control

Batch: S085101 DMSO]82 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.55%
99.55

G-1 (LNS 8801) Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description G-1 (LNS 8801) is a nonsteroidal and selective agonist of G protein-coupled receptor 30 (GPR30, G protein-coupled estrogen receptor 1, GPER) with Ki of 11 nM.
Targets
GPR30 [1]
(Cell-free assay)
11 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06351488 Not yet recruiting
Kidney Transplant Patients Eligible for a Solid Biopsy
Assistance Publique - Hôpitaux de Paris|CGenetix|Institut National de la Santé Et de la Recherche Médicale France
 June 10 2024 --
NCT06217458 Not yet recruiting
DCIS|Breast Carcinoma in Situ|Calcification
Clinical Hospital Center Rijeka
 March 1 2024 Not Applicable
NCT06178146 Recruiting
IrAE
Jun Wang|Qianfoshan Hospital
 September 1 2023 Phase 4

Chemical Information & Solubility

Molecular Weight 412.28 Formula

C21H18BrNO3
CAS No. 881639-98-1 SDF --
Smiles CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 82 mg/mL ( (198.89 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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