Home Metabolism P450 (e.g. CYP17) inhibitor Ezutromid For research use only.

Ezutromid

Synonyms: SMT C1100, BMN 195, VOX-C1100

Ezutromid (SMT C1100,BMN 195,VOX-C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM which can be used for the research Duchenne muscular dystrophy (DMD), also inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM.

Ezutromid Chemical Structure

Ezutromid Chemical Structure

CAS No. 945531-77-1

Purity & Quality Control

Batch: S041801 DMSO]4 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.72%
99.72

Ezutromid Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description Ezutromid (SMT C1100,BMN 195,VOX-C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM which can be used for the research Duchenne muscular dystrophy (DMD), also inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM.
Targets
CYP1A2 [1]
(in assay of CYP1A2 enzymic activity)
5.4 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02858362 Terminated
Duchenne Muscular Dystrophy
Summit Therapeutics
 June 2016 Phase 2
NCT02383511 Completed
Muscular Dystrophy Duchenne
Summit Therapeutics
 February 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 337.39 Formula

C19H15NO3S
CAS No. 945531-77-1 SDF --
Smiles CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)C3=CC4=CC=CC=C4C=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 4 mg/mL ( (11.85 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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