Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Dydrogesterone For research use only.

Dydrogesterone

Synonyms: NSC 92336

Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.

Dydrogesterone Chemical Structure

Dydrogesterone Chemical Structure

CAS No. 152-62-5

Purity & Quality Control

Dydrogesterone Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
Targets
progestogen Receptor [1]
In vitro
In vitro Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. [1]
In Vivo
In vivo Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. Dydrogesterone restores the percentage of CD8+ uterus cells back to levels seen in control mice. Dydrogesterone significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. Dydrogesterone results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. [2] Dydrogesterone abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. Dydrogesterone increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. Dydrogesterone dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05186779 Terminated
Early Pregnancy Bleeding|Recurrent Pregnancy Loss
Center for Epidemiology and Health Research Germany|Abbott Products Operations AG
 December 15 2021 --
NCT04287205 Completed
Endometriosis|Sexual Dysfunction
Kanuni Sultan Suleyman Training and Research Hospital
 April 20 2019 Not Applicable
NCT02706470 Unknown status
Miscarriage Recurrent
Fudan University
 May 2016 Phase 2|Phase 3
NCT01711216 Completed
Irregular Menstrual Cycle
Abbott
 August 2012 --

Chemical Information & Solubility

Molecular Weight 312.45 Formula

C21H28O2
CAS No. 152-62-5 SDF Download Dydrogesterone SDF
Smiles CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (198.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble


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In vivo
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