Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Desogestrel For research use only.

Desogestrel

Synonyms: Cerazette, Desogen, Desogestrelum, Org-2969

Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.

Desogestrel Chemical Structure

Desogestrel Chemical Structure

CAS No. 54024-22-5

Purity & Quality Control

Batch: S463801 DMSO]62 mg/mL]false]Ethanol]62 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Desogestrel Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
In Vivo
In vivo Desogestrel is extensively metabolized after oral administration to rats and dogs; In rats, desogestrel is metabolized mainly at the C3, C5, C11, and C15 positions. An hydroxy group is introduced at the 15α-position of desogestrel, followed by conjugation with glucuronic acid. In dogs, desogestrel is mainly metabolized at the C3- and C17-positions[1].
Animal Research Animal Models Female Wistar rats, Female beagle dogs
Dosages 56 μg/kg, 106 mg/kg (Rats); 67 μg/kg, 9.6 mg/kg(Dogs)
Administration oral administration

Chemical Information & Solubility

Molecular Weight 310.47 Formula

C22H30O
CAS No. 54024-22-5 SDF Download Desogestrel SDF
Smiles CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CCCCC34
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (199.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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