Home Endocrinology & Hormones Adrenergic Receptor agonist - Akt activator - PI3K activator - Apoptosis related inhibitor Demethyl-Coclaurine For research use only.

Demethyl-Coclaurine

Synonyms: Higenamine, Norcoclaurine

Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.

Demethyl-Coclaurine Chemical Structure

Demethyl-Coclaurine Chemical Structure

CAS No. 5843-65-2

Purity & Quality Control

Demethyl-Coclaurine Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.
Targets
β2-AR [1] Akt [1] PI3K [1]

Chemical Information & Solubility

Molecular Weight 271.31 Formula

C16H17NO3
CAS No. 5843-65-2 SDF --
Smiles OC1=CC=C(CC2NCCC3=CC(=C(O)C=C23)O)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 54 mg/mL ( (199.03 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 7 mg/mL

Ethanol : Insoluble


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In vivo
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