Home Neuronal Signaling Adrenergic Receptor inhibitor Carvedilol Phosphate For research use only.

Carvedilol Phosphate

Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.

Carvedilol Phosphate Chemical Structure

Carvedilol Phosphate Chemical Structure

CAS No. 610309-89-2

Purity & Quality Control

Batch: S570301 DMSO]100 mg/mL]false]]]false]]]false Purity: 98%
98

Carvedilol Phosphate Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00732511 Unknown status
Endothelial Function|Diabetes Mellitus|Hypertension
State University of New York - Downstate Medical Center
 April 2008 Phase 4
NCT00537043 Completed
Hypertension
GlaxoSmithKline
 October 2007 Phase 1
NCT00552708 Completed
Hypertension
GlaxoSmithKline
 September 2007 Phase 1
NCT00508365 Completed
Hypertension
GlaxoSmithKline
 September 25 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 513.48 Formula

C24H29N2O8P.1/2H2O
CAS No. 610309-89-2 SDF --
Smiles COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.O.OP(=O)(O)O.OP(=O)(O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (194.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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