Home Endocrinology & Hormones Estrogen/progestogen Receptor chemical Vepdegestrant (ARV471) For research use only.

Vepdegestrant (ARV471)

Vepdegestrant (ARV471) is an orally bioavailable estrogen receptor-targeting (ER-targeting) PROTAC for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer.

Vepdegestrant (ARV471) Chemical Structure

Vepdegestrant (ARV471) Chemical Structure

CAS No. 2229711-68-4

Purity & Quality Control

Batch: S986201 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.75%
99.75

Vepdegestrant (ARV471) Related Products

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

Biological Activity

Description Vepdegestrant (ARV471) is an orally bioavailable estrogen receptor-targeting (ER-targeting) PROTAC for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer.
Targets
ER [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06206837 Recruiting
Breast Cancer
Pfizer|Arvinas Estrogen Receptor Inc.
 February 19 2024 Phase 1|Phase 2
NCT06256510 Recruiting
Healthy Participants
Pfizer|Arvinas Estrogen Receptor Inc.
 February 8 2024 Phase 1
NCT06275841 Recruiting
Healthy
Pfizer|Arvinas Estrogen Receptor Inc.
 February 23 2024 Phase 1
NCT06125522 Recruiting
Breast Cancer
Pfizer|Arvinas Estrogen Receptor Inc.|Carrick Therapeutics Limited
 January 10 2024 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 723.9 Formula

C45H49N5O4
CAS No. 2229711-68-4 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (138.14 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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