Home Proteases MMP inhibitor ARP 100 For research use only.

ARP 100

Synonyms: MMP-2 Inhibitor III, Compound 10a

ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively.

ARP 100 Chemical Structure

ARP 100 Chemical Structure

CAS No. 704888-90-4

Purity & Quality Control

Batch: S990901 DMSO]73 mg/mL]false]Ethanol]73 mg/mL]false]Water]Insoluble]false Purity: 98.70%
98.70

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Signaling Pathway

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MMP Signaling Pathway

Biological Activity

Description ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively.
Targets
MMP-2 [1]
(Cell-free assay)
12 nM
In vitro
In vitro

ARP-100 interacts with S1' pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel, causing a significant reduction in the total number of invasive elongations.<sup><a class="sref" href="#s_ref">[1]</a></sup>
Cell Research Cell lines HT1080 sarcoma cells
Concentrations 50 nM
Incubation Time 1 h
Method

HT1080 sarcoma cells aer plated on matrigel in complete medium. After 24 h, HT1080 sarcoma cells incubated with ARP 100 (50 nM). Total number of invasive elongations is observed.

Chemical Information & Solubility

Molecular Weight 364.42 Formula

C17H20N2O5S
CAS No. 704888-90-4 SDF --
Smiles CC(C)ON(CC(=O)NO)[S](=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 73 mg/mL ( (200.31 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 73 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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