Home Proteases MMP inhibitor Cordycepin For research use only.

Cordycepin

Synonyms: 3'-Deoxyadenosine

Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.

Cordycepin Chemical Structure

Cordycepin Chemical Structure

CAS No. 73-03-0

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Cordycepin Related Products

Signaling Pathway

MMP Signaling Pathways

MMP Signaling Pathway

Biological Activity

Description Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.
In vitro
In vitro Cordycepin increases interleukin (IL)-10 expression, decreased IL-2 expression and suppresses T lymphocyte activity. It also up-regulates IL-1beta, IL-6, IL-8 and TNF-alpha and suppresses phytohemagglutinin (PHA)-induced production of IL-2, IL-4, IL-5, IFN-gamma and IL-12[1]. The structure of Cordycepin is very much similar with cellular nucleoside, adenosine and acts like a nucleoside analogue. Cordycepin lacks 3' hydroxyl group in its structure. It provokes RNA chain termination and interferes in mTOR signal transduction. At higher doses, Cordycepin inhibits cell attachment and reduces focal adhesion. under low nutritional stress, Cordycepin activates AMPK which blocks the activity of mTORC1 and mTORC2 complex. The inactivated mTORC2 complex cannot activate AKT 1 kinase fully, which in turn blocks mTOR signal transduction inhibiting translation and further cell proliferation and growth. Cordycepin also induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules[2]. Cordycepin has anti-tumor effect on mouse melanoma and lung carcinoma cells and human oral cancer cells[3].
Cell Research Cell lines MA-10 cells
Concentrations 10 μM, 100 μM, 1 mM, 2 mM and 5 mM
Incubation Time 24 h
Method MA-10 cells (6 × 105) are seeded in 6-cm Petri dish with 2 mL serum medium. After 70-80% confluence, cells are treated without or with 10 μM, 100 μM, 1 mM, 2 mM and 5 mM cordycepin for 24 h. Cell morphology is then observed and recorded under light microscopy. Apoptosis is characterized by the loss of cellular contact with the matrix and the appearance of plasma membrane blebbing.
In Vivo
In vivo Orally administered cordycepin inhibits melanoma cell growth in mice with no adverse effects[4]. Oral cordycepin administration at dose of 10 mg/kg significantly improves Y-maze learning performance both in healthy and ischemic mice. However, cordycepin at dose of 5 mg/kg enhanced Y-maze learning only in ischemic mice but not healthy mice. Cordycepin significantly decreases the neuronal loss induced by ischemia in hippocampal CA1 and CA3 regions[5].
Animal Research Animal Models C57BL/6Cr mice
Dosages 5 and 15 mg/kg
Administration oral
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00709215 Unknown status
Refractory TdT-Positive Leukemia
OncoVista Inc.|AAIPharma
 June 2008 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 251.24 Formula

C10H13N5O3
CAS No. 73-03-0 SDF Download Cordycepin SDF
Smiles C1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 50 mg/mL ( (199.01 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 25 mg/mL

Ethanol : 1 mg/mL


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In vivo
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