Home Proteases MMP inhibitor JNJ0966 For research use only.

JNJ0966

JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.

JNJ0966 Chemical Structure

JNJ0966 Chemical Structure

CAS No. 315705-75-0

Purity & Quality Control

JNJ0966 Related Products

Signaling Pathway

MMP Signaling Pathways

MMP Signaling Pathway

Biological Activity

Description JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.
In vitro
In vitro JNJ0966 inhibits the conversion of proMMP-9 to active MMP-9 but is not a direct inhibitor of MMP-9 or MMP-3 enzymatic activity. JNJ0966 inhibits proMMP-9 maturation[1].
In Vivo
In vivo Oral administration of JNJ0966 significantly diminishes the clinical disease score observed in the mouse EAE model[1].
Animal Research Animal Models mouse EAE model (conducted in female C57Bl/6 mice age 6-8 weeks)
Dosages 10 and 30 mg/kg
Administration by oral gavage

Chemical Information & Solubility

Molecular Weight 360.45 Formula

C16H16N4O2S2
CAS No. 315705-75-0 SDF --
Smiles CC1=C(SC(=N1)NC(=O)C)C2=CSC(=N2)NC3=CC=CC=C3OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 72 mg/mL ( (199.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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