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Formula | C16H16N4O2S2 |
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Molecular Weight | 360.45 | CAS No. | 315705-75-0 | |
Solubility (25°C)* | In vitro | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen. |
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In vitro | JNJ0966 inhibits the conversion of proMMP-9 to active MMP-9 but is not a direct inhibitor of MMP-9 or MMP-3 enzymatic activity. JNJ0966 inhibits proMMP-9 maturation[1]. |
In vivo | Oral administration of JNJ0966 significantly diminishes the clinical disease score observed in the mouse EAE model[1]. |
Animal Study: |
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Opposing MMP-9 Expression in Mesenchymal Stromal Cells and Head and Neck Tumor Cells after Direct 2D and 3D Co-Culture [ Int J Mol Sci, 2023, 24(2)1293] | PubMed: 36674806 |
G6PD upregulates Cyclin E1 and MMP9 to promote clear cell renal cell carcinoma progression [ Int J Med Sci, 2022, 19(1):47-64] | PubMed: 34975298 |
Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway. [ Cell Rep, 2020, 30(6):1780-1797] | PubMed: 32049010 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.