Anti-FLT3 / CD135

Synonyms: IMC-EB10

Catalog No.A2493 Purity:99%

Anti-FLT3 / CD135 (IMC-EB10) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. MW: 145.5 KD.

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Purity & Quality Control

Batch: A249301 Purity: 99% Protein concentration: 7.932mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective FLT3 Inhibitors

Name	Citation	FLT3	Others
Quizartinib (AC220)	135	+++
Dovitinib (TKI-258)	49	++++	c-Kit,VEGFR3/FLT4,FGFR1
Amuvatinib (MP-470)	19	+	c-Kit (D816H),PDGFRα (V561D)
Tandutinib (MLN518)	14		c-Kit,PDGFRβ,CSF-1R
TG101209	18		JAK2,RET,JAK3
KW-2449	11		Abl (T315I),Abl,FGFR1
ENMD-2076	8		RET,Aurora A,VEGFR3/FLT4
Pacritinib	16	++	JAK2 (V617F),JAK2,TYK2
TCS 359	2
TAK-659 Hydrochloride	5	++	Syk,ZAP-70,JAK3
UNC2025 HCl	9		Mer,Axl,Tyro3
AMG 925	1		CDK4
Dovitinib (TKI258) Lactate monohydrate	30		c-Kit,VEGFR3/FLT4,FGFR1
G-749	1	++++	Mer,Aurora B,RET
AZD2932	3		PDGFRβ,VEGFR-2,c-Kit
R406	✔	Syk
Go6976	✔	JAK2,PKCα,PKCβ1

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Anti-FLT3 / CD135 (IMC-EB10) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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