Home Angiogenesis FLT3 inhibitor FF-10101 For research use only.

FF-10101

FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.

FF-10101 Chemical Structure

FF-10101 Chemical Structure

CAS No. 1472797-69-5

Purity & Quality Control

Batch: S889901 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 98.04%
98.04

FF-10101 Related Products

Signaling Pathway

FLT3 Signaling Pathways

FLT3 Signaling Pathway

Biological Activity

Description FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.
Targets
FLT3 (D835Y) [1]
(Cell-free assay)		 FLT3 (WT) [1]
(Cell-free assay)
0.16 nM 0.20 nM
In vitro
In vitro

FF-10101 potently and selectively inhibits the growth of mutant FLT3-expressing leukemia cells in vitro.[1]
Cell Research Cell lines HEK293T cells
Concentrations --
Incubation Time 1 h
Method

HEK293T cells transiently expressing FLT3-ITD or FLT3-ITD-C695S are incubated with various concentrations of FF-10101 and FLA-9430 at 37°C for 1 hour.
In Vivo
In vivo

Oral administration of FF-10101 shows significant anti-leukemic effects at 5 mg/kg and 10 mg/kg twice daily for 11 days in the PDX model of AML cells with FLT3-ITD.[1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03194685 Completed
AML Adult
Fujifilm Pharmaceuticals U.S.A. Inc.
 May 5 2017 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 530.66 Formula

C29H38N8O2
CAS No. 1472797-69-5 SDF --
Smiles CCCNC1=NC(=NC=C1C#CCCCNC(=O)C(C)N(C)C(=O)C=CCN(C)C)NC2=CC=C(C=C2)C#N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (188.44 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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