Home Angiogenesis FLT3 inhibitor - Bcr-Abl inhibitor - c-RET inhibitor - c-Kit inhibitor AST-487 (NVP-AST487) For research use only.

AST-487 (NVP-AST487)

AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.

AST-487 (NVP-AST487) Chemical Structure

AST-487 (NVP-AST487) Chemical Structure

CAS No. 630124-46-8

Purity & Quality Control

Batch: S666201 DMSO]100 mg/mL]false]Ethanol]33 mg/mL]false]Water]Insoluble]false Purity: 99.87%
99.87

AST-487 (NVP-AST487) Related Products

Signaling Pathway

FLT3 Signaling Pathways

FLT3 Signaling Pathway

Biological Activity

Description AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.
Targets
RET [1] KDR [1] c-Kit [1] c-Abl [1] FLT3 [1]
(Cell-free assay)
0.12 μM(Ki)

Chemical Information & Solubility

Molecular Weight 529.56 Formula

C26H30F3N7O2
CAS No. 630124-46-8 SDF --
Smiles CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (188.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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