FF-10101

Catalog No.S8899 Batch:S889901

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Technical Data

Formula

C29H38N8O2
Molecular Weight 530.66 CAS No. 1472797-69-5
Solubility (25°C)* In vitro DMSO 100 mg/mL (188.44 mM)
Ethanol 100 mg/mL (188.44 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.
Targets
FLT3 (D835Y) [1]
(Cell-free assay)		 FLT3 (WT) [1]
(Cell-free assay)
0.16 nM 0.20 nM
In vitro

FF-10101 potently and selectively inhibits the growth of mutant FLT3-expressing leukemia cells in vitro.[1]
In vivo

Oral administration of FF-10101 shows significant anti-leukemic effects at 5 mg/kg and 10 mg/kg twice daily for 11 days in the PDX model of AML cells with FLT3-ITD.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HEK293T cells

  • Concentrations

    --

  • Incubation Time

    1 h

  • Method

    HEK293T cells transiently expressing FLT3-ITD or FLT3-ITD-C695S are incubated with various concentrations of FF-10101 and FLA-9430 at 37°C for 1 hour.

Selleck's FF-10101 has been cited by 1 publication

The Combined Treatment With the FLT3-Inhibitor AC220 and the Complex I Inhibitor IACS-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells [ Front Oncol, 2021, 11:686765] PubMed: 34490088

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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