Home Angiogenesis FLT3 inhibitor HM43239 For research use only.

HM43239

HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s' of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.

HM43239 Chemical Structure

HM43239 Chemical Structure

CAS No. 2569527-64-4

Purity & Quality Control

Batch: S989201 DMSO]50 mg/mL]false]Ethanol]12.5 mg/mL]false]Water]Insoluble]false Purity: 99.92%
99.92

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Signaling Pathway

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Biological Activity

Description

HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s' of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.
Targets
FLT3-D835Y [1] FLT3-WT [1] FLT3-ITD [1]
1.0 nM 1.1 nM 1.8 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03850574 Recruiting
Relapsed or Refractory Acute Myeloid Leukemia
Aptose Biosciences Inc.
 March 11 2019 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 501.07 Formula

C29H33ClN6
CAS No. 2569527-64-4 SDF --
Smiles CC1CN(CC(C)N1)CC2=CC(=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=C4C=CC(=C5)C)C6CC6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 50 mg/mL ( (99.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12.5 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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