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Amoxicillin

Name: Amoxicillin
Brand: Selleck Chemicals
SKU: S3015
Rating: 5 (5 reviews)

Synonyms: Amoxycillin

Catalog No.S3015 Purity:99.69%

Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.

Amoxicillin Chemical Structure

CAS No. 26787-78-0

Purity & Quality Control

Batch: Purity: 99.69%

99.69

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Biological Activity

Description	Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.

In vitro
In vitro	Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. Amoxicillin-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. ^[1] Amoxicillin releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. Amoxicillin would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that amoxicillin is not stable in an acidic surrounding. ^[2] Amoxicillin inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. ^[3] Amoxicillin inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL. ^[4]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05464615	Recruiting	Penicillin Allergy	Geisinger Clinic	March 4 2024	Early Phase 1
NCT04408508	Not yet recruiting	Penicillin Allergy	Saskatchewan Health Authority - Regina Area	December 2023	Not Applicable
NCT05309928	Recruiting	Pregnancy Related	University of Alabama at Birmingham	August 29 2023	Phase 1
NCT05584683	Recruiting	Pediatric\|Bacterial Infections	Kaizen Bioscience Co.	August 9 2023	Phase 1
NCT05340257	Not yet recruiting	Infections Bacterial	GlaxoSmithKline	June 23 2023	Phase 2

References

[4] Mainardi JL, et al. Antimicrob Agents Chemother, 1995, 39(9), 1984-1987.

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Chemical Information & Solubility

Molecular Weight	365.4	Formula	C₁₆H₁₉N₃O₅S
CAS No.	26787-78-0	SDF	Download Amoxicillin SDF
Smiles	CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 73 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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