Amoxicillin

Catalog No.S3015 Batch:S301501

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Technical Data

Formula

C16H19N3O5S
Molecular Weight 365.4 CAS No. 26787-78-0
Solubility (25°C)* In vitro DMSO 73 mg/mL (199.78 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.
In vitro Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. Amoxicillin-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. [1] Amoxicillin releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. Amoxicillin would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that amoxicillin is not stable in an acidic surrounding. [2] Amoxicillin inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. [3] Amoxicillin inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL. [4]

Protocol (from reference)

Selleck's Amoxicillin has been cited by 5 publications

Stability of 10 Beta-Lactam Antibiotics in Human Plasma at Different Storage Conditions [ Ther Drug Monit, 2023, 10.1097/FTD.0000000000001100] PubMed: 37199408
High-throughput analysis for the simultaneous quantification of nine beta-lactam antibiotics in human plasma by UPC2-MS/MS: Method development, validation, and clinical application [ J Pharm Biomed Anal, 2022, 219:114904] PubMed: 35772234
Desorption Electrospray Ionization Mass Spectrometry Assay for Label-Free Characterization of SULT2B1b Enzyme Kinetics [ ChemMedChem, 2022, e202200043] PubMed: 35080134
A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro [ PLoS Comput Biol, 2020, 16(12):e1008489] PubMed: 33382685
Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types. [Doherty KR, et al. Toxicol Appl Pharmacol, 2015, 285(1):51-60] PubMed: 25841593

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.